So about this 20% business.  


Today I am in hospital today for Cycle 2, Day 1 of the clinical trial, and I had a word about the whole 20%-growth-and-you’re-out thing with Naz, my incredibly competent, compassionate and sensible nurse.


She sat down on the bed and looked me in the eye, and asked in a way that I hope I remember to employ when reasoning with my future teenager: “Well, what would you want to do if the CT scan were to show that these lumps are growing?  Would you want to continue with a drug that isn’t working for you?”


No, I admitted, I would not.  I would however like the drug and I to be given a fighting chance of working together toward the common goal of cancer obliteration (apoptosis!) before we are ripped asunder. I’ve tried chemo and radiation, and now I’d like a fair shot at the wonderful world of HDAC-inhibitors.  Perhaps they could just adjust the dose?


Negative.  This clinical trial, as Naz explained, is at a stage where the dose has been firmly established based on things like toxicity tolerances and disease response, and they’re just not going to give me more than I’m getting right now, period. But they do want to give the drug a chance to do its thing, which is why they’ll wait a full two cycles to see if it’s working.  


A full two cycles. That may sound generous but it boils down to just four doses total, next Wednesday’s being the last. The CT scan is already booked for the following week, August 26th.  Clearly Panobinostat and I are on the clock.


Take heart: I actually think we can do this.  I’m going to go with the idea that this is the beginning of a long and mutually satisfying relationship between me and Panobinostat, rather than a whirlwind summer fling.  Bonnie & Clyde, Batman & Robin, Leanne & Panobinostat.  I do the tough talking — Shrink, damn you. You’ve got 2 weeks to make like a couple of raisins and shrivel — and Panobinostat is the muscle.   


Cancer, you’ve been warned.





Filed under Living with Breast Cancer

2 responses to “Teamwork

  1. Aunty Carol

    Hi Leanne, hope you had a good time at the Deb Ball. Wish I could have been there. It must be so different now that so many of you have children – a whole new focus.
    I wanted to ask you a question. So much is going on in the US right now with regard to health care and how if the US adopted anything similar to the Canadian or British Plans, people would be waiting months for treatment, care would not be as good as in the US, and old people would not get necessary treatment, simply due to the fact they are old and why spend health care dollars on those who are only going to die soon anyway.
    Personally, I always had a positive experience with Canadian health care and the care given to my Mom in the days before she passed was wonderful and so compassionate.
    I would like to get your viewpoint on the care you have and are being given to be current on how Canada is really doing. It is a great topic of conversation at work and I certainly am odd man out.

    Love you bunches and keep up the good fight. You are definitely my hero.


  2. Andrea Sz

    You rock. Every time. I pick up the threads after months of being away, and time and again you blow my mind with your perceptions, your clarity, your expressiveness, creativity, bravery and honesty.
    In deference to your Aunty, above, I’m trying desperately not to swear. You rock.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s